How It Works
Cavitation Process
- Fluidic bubble formation in the presence of a large pressure gradient
- As pressure increases bubbles collapse resulting in “jetting”
- Jetting drives surrounding fluid into adjacent surface
- When fluid contains a compound and the adjacent surface is tissue, the compound is driven into the tissue
Technological Capabilities
- Formulation-independent, ultra-rapid delivery of small molecules, biologics, and nucleic acids
- Demonstrated safety in small and large animal models
- Superior efficacy in a preclinical disease models
Scientific Publications
Nature Outlook ○ Special Delivery for the Gut
Science Translational Medicine ○ Ultrasound-Mediated Gastrointestinal Drug Delivery
Gastroenterology ○ Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice
Angewandte Chemie ○ Convergence for Translation: Drug-Delivery Research in Multidisciplinary Teams
Journal of Controlled Release ○ Defining Optimal Permeant Characteristics for Ultrasound-Mediated Gastrointestinal Delivery
Journal of Controlled Release ○ Ultra-Rapid Drug Delivery in the Oral Cavity using Ultrasound
Tissue Barriers ○ Of Microneedles and Ultrasound: Physical Modes of Gastrointestinal Macromolecule Delivery
Expert Opinion on Drug Delivery ○ Low-Frequency Ultrasound for Drug Delivery in the Gastrointestinal Tract
Science ○ Creating Things That Could Change the World
Science Translational Medicine ○ Ultrasound-Mediated Gastrointestinal Drug Delivery
Gastroenterology ○ Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice
Angewandte Chemie ○ Convergence for Translation: Drug-Delivery Research in Multidisciplinary Teams
Journal of Controlled Release ○ Defining Optimal Permeant Characteristics for Ultrasound-Mediated Gastrointestinal Delivery
Journal of Controlled Release ○ Ultra-Rapid Drug Delivery in the Oral Cavity using Ultrasound
Tissue Barriers ○ Of Microneedles and Ultrasound: Physical Modes of Gastrointestinal Macromolecule Delivery
Expert Opinion on Drug Delivery ○ Low-Frequency Ultrasound for Drug Delivery in the Gastrointestinal Tract
Science ○ Creating Things That Could Change the World